Pemetrexed 100

Pemetrexed 100 mg Injection
Pemetrexed 100 mg Injection is a multitargeted antifolate antineoplastic agent used primarily in the treatment of certain lung cancers and mesothelioma. It inhibits multiple enzymes involved in folate metabolism and DNA synthesis, thereby preventing cancer cell replication. Pemetrexed is widely used in modern oncology protocols, often in combination with platinum-based chemotherapy.
Product Details
Generic Name: Pemetrexed (as Pemetrexed Disodium)
Strength: 100 mg
Dosage Form: Injection (Sterile lyophilized powder for reconstitution)
Route of Administration: Intravenous (IV infusion)
Therapeutic Class: Antifolate Anticancer Agent
Indications
Pemetrexed 100 mg Injection is indicated for the treatment of:
Non-small cell lung cancer (NSCLC)
Malignant pleural mesothelioma
Maintenance therapy in advanced lung cancer (as prescribed)
Mechanism of Action
Pemetrexed inhibits key folate-dependent enzymes such as thymidylate synthase and dihydrofolate reductase, disrupting DNA and RNA synthesis in cancer cells.
Key Benefits
Targeted antifolate action against cancer cells
Proven efficacy in lung cancer and mesothelioma
Widely used in combination and maintenance therapy regimens
Accepted in global oncology treatment guidelines
Dosage & Administration
Dosage and infusion schedule are determined by the oncologist based on body surface area (BSA), indication, and patient condition. Administration must be done under strict medical supervision.
Storage Conditions
Store below 25°C
Protect from light
Do not freeze
Precautions
For hospital and oncology clinic use only
Folic acid and vitamin B12 supplementation is recommended
Monitor blood counts and renal function regularly
Use with caution in patients with renal impairment